Trichoplein/mitostatin regulates endoplasmic reticulum–mitochondria juxtaposition
نویسندگان
چکیده
منابع مشابه
Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition.
Trichoplein/mitostatin (TpMs) is a keratin-binding protein that partly colocalizes with mitochondria and is often downregulated in epithelial cancers, but its function remains unclear. In this study, we report that TpMs regulates the tethering between mitochondria and endoplasmic reticulum (ER) in a Mitofusin 2 (Mfn2)-dependent manner. Subcellular fractionation and immunostaining show that TpMs...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2010
ISSN: 1469-221X,1469-3178
DOI: 10.1038/embor.2010.151